High Evidence Drugs
Priority candidates for clinical evaluation
Evidence Standards
| Level | Definition | Clinical Significance |
|---|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews | Strong support, consider clinical use |
| L2 | Single RCT or multiple Phase 2 trials | Moderate support, design validation trials |
Drug List
L1 Level (192 drugs)
| Drug Name | Predictions | Link |
|---|---|---|
| Acetylsalicylic Acid | 9 | View Report |
| Amphotericin B | 5 | View Report |
| Arsenic Trioxide | 10 | View Report |
| Ascorbic Acid | 10 | View Report |
| Asfotase Alfa | 10 | View Report |
| Beclomethasone Dipropionate | 5 | View Report |
| Brentuximab Vedotin | 10 | View Report |
| Budesonide | 5 | View Report |
| Bumetanide | 1 | View Report |
| Bupropion | 10 | View Report |
| Cabergoline | 5 | View Report |
| Cabozantinib | 10 | View Report |
| Caffeine | 5 | View Report |
| Calcitriol | 7 | View Report |
| Calcium Carbonate | 5 | View Report |
| Calcium Chloride | 5 | View Report |
| Capecitabine | 5 | View Report |
| Carbamazepine | 5 | View Report |
| Carbidopa | 5 | View Report |
| Carboplatin | 10 | View Report |
| Ceftazidime | 5 | View Report |
| Celecoxib | 5 | View Report |
| Cephalexin | 5 | View Report |
| Cetuximab | 10 | View Report |
| Chloramphenicol | 5 | View Report |
| Chlordiazepoxide | 10 | View Report |
| Cholecalciferol | 7 | View Report |
| Cimetidine | 5 | View Report |
| Ciprofloxacin | 5 | View Report |
| Citalopram | 5 | View Report |
| Citric Acid | 8 | View Report |
| Clarithromycin | 5 | View Report |
| Clavulanic Acid | 5 | View Report |
| Clobetasol Propionate | 5 | View Report |
| Clotrimazole | 5 | View Report |
| Cyanocobalamin | 5 | View Report |
| Dasatinib | 10 | View Report |
| Decitabine | 5 | View Report |
| Deferasirox | 5 | View Report |
| Delamanid | 7 | View Report |
| Desloratadine | 5 | View Report |
| Desonide | 10 | View Report |
| Dexamethasone | 5 | View Report |
| Dupilumab | 10 | View Report |
| Entacapone | 5 | View Report |
| Entecavir | 10 | View Report |
| Enzalutamide | 7 | View Report |
| Epinephrine | 4 | View Report |
| Erythromycin | 5 | View Report |
| Estradiol Valerate | 10 | View Report |
| Etanercept | 6 | View Report |
| Ethinylestradiol | 5 | View Report |
| Etoposide | 10 | View Report |
| Everolimus | 5 | View Report |
| Ezetimibe | 5 | View Report |
| Famotidine | 5 | View Report |
| Fenofibrate | 5 | View Report |
| Ferrous Fumarate | 5 | View Report |
| Filgrastim | 10 | View Report |
| Fluconazole | 5 | View Report |
| Fluorouracil | 10 | View Report |
| Flutamide | 10 | View Report |
| Fluticasone Furoate | 8 | View Report |
| Fluticasone Propionate | 5 | View Report |
| Folic Acid | 5 | View Report |
| Gimeracil | 10 | View Report |
| Gliclazide | 5 | View Report |
| Golimumab | 5 | View Report |
| Haloperidol | 10 | View Report |
| Hydrochlorothiazide | 5 | View Report |
| Hydrocortisone | 5 | View Report |
| Hydrocortisone Acetate | 5 | View Report |
| Hydroxyurea | 10 | View Report |
| Ibuprofen | 5 | View Report |
| Iloprost | 9 | View Report |
| Imipenem | 10 | View Report |
| Imiquimod | 10 | View Report |
| Indomethacin | 10 | View Report |
| Insulin Aspart | 10 | View Report |
| Insulin Degludec | 6 | View Report |
| Insulin Detemir | 10 | View Report |
| Insulin Glargine | 5 | View Report |
| Insulin Glulisine | 10 | View Report |
| Insulin Human | 5 | View Report |
| Ipilimumab | 2 | View Report |
| Irbesartan | 5 | View Report |
| Iron | 5 | View Report |
| Isoniazid | 1 | View Report |
| Ketoconazole | 5 | View Report |
| Ketoprofen | 10 | View Report |
| Lamivudine | 5 | View Report |
| Lamotrigine | 5 | View Report |
| Ledipasvir | 10 | View Report |
| Lenalidomide | 5 | View Report |
| Levetiracetam | 10 | View Report |
| Levodopa | 5 | View Report |
| Lovastatin | 6 | View Report |
| Magnesium Hydroxide | 5 | View Report |
| Magnesium Sulfate | 10 | View Report |
| Magnesium Trisilicate | 5 | View Report |
| Mannitol | 10 | View Report |
| Medroxyprogesterone Acetate | 5 | View Report |
| Megestrol Acetate | 10 | View Report |
| Meloxicam | 5 | View Report |
| Mercaptopurine | 10 | View Report |
| Mesalazine | 7 | View Report |
| Methotrexate | 5 | View Report |
| Methylphenidate | 4 | View Report |
| Methylprednisolone | 5 | View Report |
| Metronidazole | 5 | View Report |
| Midazolam | 1 | View Report |
| Minoxidil | 10 | View Report |
| Mometasone Furoate | 5 | View Report |
| Moroctocog Alfa | 8 | View Report |
| Naproxen | 5 | View Report |
| Netarsudil | 2 | View Report |
| Nitric Oxide | 10 | View Report |
| Norethisterone | 1 | View Report |
| Obinutuzumab | 3 | View Report |
| Ofatumumab | 8 | View Report |
| Olanzapine | 5 | View Report |
| Olaparib | 1 | View Report |
| Omalizumab | 10 | View Report |
| Omeprazole | 5 | View Report |
| Oxcarbazepine | 10 | View Report |
| Paclitaxel | 5 | View Report |
| Paliperidone | 10 | View Report |
| Pantoprazole | 6 | View Report |
| Pegaspargase | 10 | View Report |
| Pembrolizumab | 10 | View Report |
| Perampanel | 10 | View Report |
| Perphenazine | 10 | View Report |
| Pertuzumab | 10 | View Report |
| Phenol | 8 | View Report |
| Plerixafor | 7 | View Report |
| Posaconazole | 1 | View Report |
| Potassium Chloride | 5 | View Report |
| Potassium Citrate | 10 | View Report |
| Prednisolone | 5 | View Report |
| Prednisolone Acetate | 10 | View Report |
| Pregabalin | 5 | View Report |
| Progesterone | 5 | View Report |
| Propylene Glycol | 10 | View Report |
| Propylthiouracil | 3 | View Report |
| Ramipril | 10 | View Report |
| Ranibizumab | 10 | View Report |
| Ranitidine | 10 | View Report |
| Revefenacin | 2 | View Report |
| Rifampicin | 10 | View Report |
| Rilpivirine | 5 | View Report |
| Riluzole | 10 | View Report |
| Risankizumab | 10 | View Report |
| Risperidone | 5 | View Report |
| Rituximab | 5 | View Report |
| Salbutamol | 10 | View Report |
| Salicylic Acid | 5 | View Report |
| Serine | 10 | View Report |
| Simoctocog Alfa | 10 | View Report |
| Simvastatin | 5 | View Report |
| Sirolimus | 10 | View Report |
| Sodium Citrate | 5 | View Report |
| Sofosbuvir | 8 | View Report |
| Sunitinib | 10 | View Report |
| Tacrolimus | 3 | View Report |
| Tadalafil | 5 | View Report |
| Tazobactam | 2 | View Report |
| Tegafur | 10 | View Report |
| Telmisartan | 5 | View Report |
| Temozolomide | 2 | View Report |
| Teriflunomide | 1 | View Report |
| Testosterone | 5 | View Report |
| Theophylline | 5 | View Report |
| Thiotepa | 5 | View Report |
| Ticagrelor | 10 | View Report |
| Tiotropium | 10 | View Report |
| Tobramycin | 5 | View Report |
| Tocilizumab | 10 | View Report |
| Tolnaftate | 5 | View Report |
| Tolvaptan | 10 | View Report |
| Topiramate | 9 | View Report |
| Trastuzumab | 10 | View Report |
| Trastuzumab Emtansine | 4 | View Report |
| Triamcinolone | 5 | View Report |
| Trimethoprim | 5 | View Report |
| Ustekinumab | 10 | View Report |
| Valproic Acid | 10 | View Report |
| Valsartan | 5 | View Report |
| Velpatasvir | 10 | View Report |
| Venetoclax | 10 | View Report |
| Vildagliptin | 10 | View Report |
| Zidovudine | 6 | View Report |
| Zinc Oxide | 5 | View Report |
L2 Level (37 drugs)
| Drug Name | Predictions | Link |
|---|---|---|
| Acetic Acid | 9 | View Report |
| Calcium Lactate | 2 | View Report |
| Ceftriaxone | 7 | View Report |
| Chlorthalidone | 10 | View Report |
| Danazol | 10 | View Report |
| Denosumab | 2 | View Report |
| Efavirenz | 3 | View Report |
| Elosulfase Alfa | 9 | View Report |
| Emtricitabine | 3 | View Report |
| Eptinezumab | 1 | View Report |
| Erenumab | 1 | View Report |
| Felodipine | 7 | View Report |
| Flurbiprofen | 10 | View Report |
| Gemfibrozil | 10 | View Report |
| Glycine | 5 | View Report |
| Lactulose | 8 | View Report |
| Lansoprazole | 2 | View Report |
| Lemborexant | 1 | View Report |
| Levofloxacin | 10 | View Report |
| Levonorgestrel | 6 | View Report |
| Lorlatinib | 10 | View Report |
| Magnesium Carbonate | 10 | View Report |
| Melphalan | 10 | View Report |
| Miconazole | 1 | View Report |
| Moclobemide | 2 | View Report |
| Moxifloxacin | 10 | View Report |
| Nitrazepam | 3 | View Report |
| Norfloxacin | 5 | View Report |
| Oxaliplatin | 4 | View Report |
| Prilocaine | 10 | View Report |
| Pyrazinamide | 10 | View Report |
| Rimegepant | 6 | View Report |
| Romiplostim | 10 | View Report |
| Tenecteplase | 10 | View Report |
| Trabectedin | 1 | View Report |
| Travoprost | 10 | View Report |
| Zinc Gluconate | 10 | View Report |
How Evidence Levels Are Determined
Evidence levels are assigned based on the quality and quantity of clinical evidence:
- Clinical Trials: Phase 3 RCTs carry the highest weight
- Systematic Reviews: Meta-analyses of multiple studies
- Study Design: Randomized controlled trials > observational studies
- Sample Size: Larger studies provide stronger evidence
Disclaimer
Drug repurposing predictions are for research purposes only. These predictions have not been clinically validated and should not be used for medical decisions. Always consult healthcare professionals.
Drug repurposing predictions are for research purposes only. These predictions have not been clinically validated and should not be used for medical decisions. Always consult healthcare professionals.